Utero-Cardiac Reflex (UCR) saat Vaginal Histerektomi dengan Anestesi Umum pada Pasien Hipertensi

  • Fitri Sepviyanti Sumardi Universitas Pembangunan Nasional ‘Veteran’ Jawa Timur
  • Dewi Yulianti Bisri Faculty of Medicine Universitas Padjadjaran Bandung
  • Tatang Bisri Faculty of Medicine Universitas Brawijaya MalangJenderal Achmad yani Cimahi-Bandung
Keywords: refleks uterokardiak, histerektomi, hipertensi

Abstract

Utero-cardiac reflex (UCR) adalah istilah yang spesifik untuk menggambarkan refleks yang terjadi ketika uterus distimulasi, menyebabkan perubahan pada fungsi jantung. Refleks ini dapat dipicu oleh berbagai faktor termasuk distensi uterus dan manipulasi uterus selama prosedur obstetrik atau ginekologik. UCR dapat menimbulkan hipotensi dan bradikardi yang dapat menyebabkan implikasi klinis signifikan terutama dalam pengelolaan pasien dengan kondisi jantung yang mendasarinya. Seorang perempuan dengan 3 anak, usia 62 tahun, berat badan 62 kg, di diagnosa prolaps uteri dan akan dilakukan tindakan vaginal histerektomi. Dilakukan endotracheal anestesi dengan N2O/O2, sevofluran, atracurium, fentanyl. Pada saat menarik uterus terjadi penurunan tiba-tiba denyut jantung menjadi 30 x/menit. Diminta dokter obgin menghentikan tindakan dan diberikan sulfas atropin 0,5 mg intravena. Denyut jantung naik menjadi 54 kali per menit dan operator dipersilahkan melanjutkan tindakannya. Akan tetapi, begitu dilakukan penarikan uterus lagi, denyut jantung turun lagi menjadi 34 kali permenit, dan diberikan 0,25 mg sulfas atropin lagi dan operator diminta untuk menghentikan tindakannya. Denyut nadi naik lagi menjadi 56 x/menit. dan operator dipersilahkan melakukan tindakannya lagi. Setelah itu, tidak terjadi lagi penurunan denyut jantung sampai dengan operasi selesai

Downloads

Download data is not yet available.

Author Biographies

Dewi Yulianti Bisri, Faculty of Medicine Universitas Padjadjaran Bandung

Department Anesthesiology and Intensive Care Padjadjaran Hospital Jatinangor Sumedang-Bandung

Tatang Bisri, Faculty of Medicine Universitas Brawijaya MalangJenderal Achmad yani Cimahi-Bandung

Department of Anesthesiology and Intensive Care Melinda Hospital Bandung

References

SZ. Hysterectomy is associated with higher risk of coronary artery disease. A nationwide retrospective cohort study in Taiwan. Medicine (Baltimore) 2018 Apr 20; 97(16): e0421. Doi: 10.1097/MD.0000000000010421.

Yuk JS, Kim BG, Lee BK, Seo J, Kim GS, Min K, et al. Association of early hysterectomy with risk of cardiovascular disease in Korean women. JAMA Netw Open 2023;6(6):e2317145. Doi: 10.1001/jamanetworkopen.2023.17145.

Matthews KA, Gibson CJ, El Khoudary SR, Thurston RC. Changes in cardiovascular risk factors by hysterectomy status with and without oophorectomy: study of women's health across the nation. J Am Coll Cardiol 2013;62:191–200. Doi: 10.1016/j.jacc.2013.04.042

Howard BV, Kuller L, Langer R, Manson JE, Allen C, Assaf A, et al. Risk of cardiovascular disease by hysterectomy status, with and without oophorectomy. Circulation 2005;111:1462–70. Doi: 10.1161/01.CIR.0000159344.21672.FD

Parker WH. Bilateral oophorectomy versus ovarian conservation: effects on long-term women's health. J Minim Invasive Gynecol 2010;17:161–6. Doi: 10.1016/j.jmig.2009.12.016

Ingelsson E, Lundholm C, Johansson ALV, Altman D. Hysterectomy and risk of cardiovascular disease: a population-based cohort study. Eur Heart J 2011;32:745–50. Doi: 10.1093/eurheartj/ehq477

Olmos-Ramírez RL, Peña-Castillo MÁ, Mendieta-Zerón H, Reyes-Lagos JJ. Uterine activity modifies the response of the fetal autonomic nervous system at preterm active labor. Front Endocrinol (Lausanne). 2023;13:1056679. Doi:10.3389/fendo.2022.1056679

Rodríguez S, Gil-Molina A, Cañadas-Villar MA, Domínguez-Ramos T, Rodríguez-Oliva MS. Vasovagal syncope during office hysteroscopy — a review. J Clin Med. 2022;11(21):6312. Doi:10.3390/jcm11216312

Imai E, Kamijyo S, Namekawa M, Yokozuka M. Robotic-assisted laparoscopic hysterectomy and vasovagal reflex: A case report. Clin Case Rep. 2022;10(4):e05778. Doi:10.1002/ccr3.5778

Kyejo W, Mwandemele H, Kidenya B. Cervical vasovagal shock: a rare complication of incomplete abortion — case series and review. Case Rep Womens Health. 2022;36:e0040. doi:10.1016/j.crwh.2022.e00401.

Imai E, Kamijyo S, Namekawa M, Yokozuka M. Robotic-assisted laparoscopic hysterectomy and vasovagal reflex: A case report. Clin Case Rep 2022 Apr 20;10(4):e05778. Doi: 10.1002/ccr3.5778

Chikazawa K, Yoshida C, Kuwata T, Konno R. Vaginal incision during total laparoscopic hysterectomy may cause severe bradycardia and cardiac arrest. Taiwan J Obstet Gynecol. 2018;57:468–69. Doi: 10.1016/j.tjog.2018.04.028

Recher M, Lauriot Dit Prevost A, Sharma D, De Jonckheere J, Garabedian C, Storme L. Roles of parasympathetic outflow and sympathetic outflow in the cardiovascular response to brief umbilical cord occlusion in fetal sheep. PLoS ONE. 2021;16(7):e0254155. Doi:10.1371/journal.pone.0254155.

Papadopoulos GE, Evaggelou TI, Moulias EK, Tsonis O, Zekios KC, Nikas DN, et al. Autonomic responses during labor: potential implications for Takotsubo syndrome. J Cardiovasc Dev Dis. 2021;8(11):152. Doi:10.3390/jcdd8110152.

Tarvonen MJ, Lear CA, Andersson S, Gunn AJ, Teramo KA. Increased variability of fetal heart rate during labour: a review of preclinical and clinical studies. BJOG. 2022;129(13):2070–81. Doi:10.1111/1471-0528.17234.

Shaw CJ, Allison BJ, Itani N, Botting KJ, Niu Y, Lees CC, Giussani DA. Altered autonomic control of heart rate variability in the chronically hypoxic fetus. J Physiol. 2018;596(23):6105–19. Doi: 10.1113/JP275659.

Tournier A, Beacom M, Westgate JA, Bennet L, Garabedian C, Ugwumadu A, Gunn AJ, Lear CA. Physiological control of fetal heart rate variability during labour: implications and controversies. J Physiol. 2022;600(3):431–50. Doi: 10.1113/JP282276.

Grassi G, Quarti-Trevano F, Seravalle G, Dell’Oro R, Vanoli J, Persghin G, et al. Sympathetic neural mechanisms underlying attended and unattended blood pressure Measurement. Hypertension. 2021;78:1126–1133. doi:10.1161/HYPERTENSIONAHA.121.17657.

Hoang JD, Vaseghi M. No sympathy for the hypoxic: the role of fetal oxygenation in autonomic dysfunction. J Physiol. 2018;596(23):5507–508. Doi:10.1113/JP276227.

Zhou C, Huang X, Zhuo Z, Wu Q, Liu M, Li S. Effect of different anesthesia depths on perioperative heart rate variability and hemodynamics in middle-aged and elderly patients undergoing general anesthesia. BMC Anesthesiol. 2024;24:312. Doi:10.1186/s12871-024-02700-9

CROSSMARK
Published
2025-11-18
DIMENSIONS
Section
Case Report

Most read articles by the same author(s)