Left Ventricular Ejection Fraction (LVEF) dan Klasifikasi New York Heart Association (NYHA) sebagai Prediktor Mortalitas Pascaanestesi untuk Persalinan dengan Penyakit Jantung
Abstract
Latar Belakang: Klasifikasi New York Heart Association (NYHA) mengkategorikan pasien berdasarkan tingkat keparahan gejala jantung. Fraksi ejeksi ventrikel kiri Left Ventricular Ejection Fraction (LVEF) juga penting, sebagai prediktor luaran bagi wanita hamil dengan penyakit jantung. Hingga kini, penelitian mengenai hubungan antara LVEF, klasifikasi NYHA, dan luaran anestesi obstetri masih terbatas, terutama di negara berkembang.
Tujuan: Menilai apakah LVEF dan klasifikasi NYHA dapat memprediksi mortalitas pasca analgesia dan anestesi pada ibu hamil dengan penyakit jantung.
Subjek dan Metode: Studi kohort retrospektif dari data sekunder pasien hamil, penyakit jantung tahun 2019–2022 menggunakan analisis deskriptif dan bivariat untuk mengetahui hubungan variabel bebas dengan luaran mortalitas.
Hasil: Pemeriksaan rekam medis antara tahun 2019–2022 terhadap 74 subjek menunjukkan rerata usia 29,3 tahun. Terdapat 6 subjek meninggal. Hubungan signifikan antara klasifikasi NYHA dan mortalitas pasca analgesia atau anestesi (p=0,045), terutama NYHA Kelas IV (p=0,031; OR 16,5; CI95% 1,82 – 149,591). LVEF abnormal (p=0,031; OR 9,167; CI 95% 1,012 – 83,051) juga menunjukkan hubungan positif dengan mortalitas pasca analgesia atau anestesi dibandingkan dengan LVEF normal (LVEF 50–70%).
Simpulan: Klasifikasi NYHA dan LVEF dapat memprediksi bermakna mortalitas pasca analgesia atau pasca anestesi pada persalinan ibu hamil dengan penyakit jantung
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References
Tsen LC, Bateman BT. Anesthesia for cesarean delivery. Dalam: Chestnut DH, Wong CA, Tsen LC, Ngan Kee WD, Beilin Y, Mhyre JM, et al., editors. 6th edition Chestnut’s obstetric anesthesia: principles and practice.. St. Louis, MO: Elsevier; 2019, 568–626.
Regitz-Zagrosek V, Roos-Hesselink JW, Bauersachs J, Blomström-Lundqvist, Renata Cífková C, De Bonis M, et al. 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy. Eur Heart J. [cited 2023 Nov 17] 2018;39(34):3165–241. [Internet].Tersedia dari: https://academic.oup.com/eurheartj/article/39/34/3165/5078465
Wei J, Merz CNB. General considerations. Dalam: Zagrosek-Regitz V, editor. ESC CardioMed. [Internet]. Oxford University Press. [cited 2023 Nov 17]. 2018, 2847–850. Tersedia dari: https://academic.oup.com/esc/book/35489/chapter/312433824
Anwar AD, Winarno GN, Anggraeni EN. Correlation between risk or severity of heart failure and outcome of pregnancy. Int J Gen Med. [Internet]. 2020 May [cited 2023 Oct 29];Volume 13:201–6. Tersedia dari: https://www.dovepress.com/correlation-between-risk-or-severity-of-heart-failure-and-outcome-of-p-peer-reviewed-article-IJGM
Muninggar L, Yusuf M, Prasetyo B. Maternal mortality risk factor in pregnancy with heart disease at Dr. Soetomo General Hospital, Surabaya, Indonesia. MOG [Internet]. 2019;27(1):17. [cited 2023 Oct 29]. Tersedia dari: https://e-journal.unair.ac.id/MOG/article/view/13083
McCall S, Nair M, Knight M. Factors associated with maternal mortality at advanced maternal age: a population-based case–control study. BJOG [Internet]. 2017;124(8):1225–33. [cited 2023 Oct 29]. Tersedia dari: https://obgyn.onlinelibrary.wiley.com/doi/10.1111/1471-0528.14216
Tanaka H, Hasegawa J, Katsuragi S, Tanaka K, Arakaki T, Nakamura M, et al. High maternal mortality rate associated with advanced maternal age in Japan. Sci Rep [Internet]. 2023;13(1):12918. [cited 2023 Oct 29]Tersedia dari: https://www.nature.com/articles/s41598-023-40150-4
Lee KK, Raja EA, Lee AJ, Bhattacharya S, Bhattacharya S, Norman JE, et al. Maternal obesity during pregnancy associates with premature mortality and major cardiovascular events in later life. Hypertension [Internet]. 2015;66(5):938–44. [cited 2023 Oct 29]. Tersedia dari: https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.115.05920
Patel SD, Habib AS. Anaesthesia for the parturient with obesity. BJA Education [Internet]. 2021;21(5):180–6. [cited 2023 Oct 29]. Tersedia dari: https://linkinghub.elsevier.com/retrieve/pii/S2058534921000032
Avila WS, Ribeiro VM, Rossi EG, Binotto MA, Bortolotto MR, Testa C, et al. Pregnancy in women with complex congenital heart disease. A Constant Challenge. Arq Bras Cardiol. [Internet]. 2019. [cited 2023 Oct 29]. Tersedia dari: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2019001201062
Wu P, Gulati M, Kwok CS, Wong CW, Narain A, O’Brien S, et al. Preterm delivery and future risk of maternal cardiovascular disease: A systematic review and meta-analysis. J Am Heart Assoc. [Internet]. 2018;7(2):e007809. [cited 2023 Oct 29] Tersedia dari: https://www.ahajournals.org/doi/10.1161/JAHA.117.007809
Muñoz-Ortiz E, Gándara-Ricardo JA, Velásquez-Penagos JA, Giraldo-Ardila N, Betancur-Pizarro AM, Arévalo-Guerrero EF, et al. Factores de riesgo para complicaciones cardíacas, obstétricas y neonatales en pacientes con enfermedad cardíaca durante el embarazo. Arch Cardiol Mex. [Internet]. 2020;90(2):2753. [cited 2023 Oct 29]Tersedia dari: http://www.archivoscardiologia.com/frame_esp.php?id=148
Guimarães T, Magalhães A, Veiga A, Fiuza M, Ávila W, Pinto FJ. Heart disease and pregnancy: State of the art. Rev Port de Cardiol. [Internet]. 2019;38(5):373–83. [cited 2023 Nov 10]. Tersedia dari: https://linkinghub.elsevier.com/retrieve/pii/S2174204919301503
Sobhy S, Zamora J, Dharmarajah K, Arroyo-Manzano D, Wilson M, Navaratnarajah R, et al. Anaesthesia-related maternal mortality in low-income and middle-income countries: a systematic review and meta-analysis. Lancet Glob Health. [Internet]. 2016;4(5):e320–7. [cited 2023 Oct 29]. Tersedia dari: https://linkinghub.elsevier.com/retrieve/pii/S2214109X16300031
Gotsman I, Leibowitz D, Keren A, Amir O, Zwas DR. Echocardiographic characteristics and clinical outcomes of the hyperdynamic heart: a ‘super-normal’ heart is not a normal heart. Am J Cardio. [Internet]. 2023;187:119–26. [cited 2023 Nov 10]. Tersedia dari: https://linkinghub.elsevier.com/retrieve/pii/S0002914922011171
Wehner GJ, Jing L, Haggerty CM, Suever JD, Leader JB, Hartzel DN, et al. Routinely reported ejection fraction and mortality in clinical practice: where does the nadir of risk lie? Euro Heart J. [Internet]. 2020;41(12):1249–57. [cited 2023 Nov 10]. Tersedia dari: https://academic.oup.com/eurheartj/article/41/12/1249/5544337
Sharma N, Khan D, Das R, Jethani R, Panda S. Maternal mortality and predictors of adverse outcome in patients with heart disease in pregnancy. J Family Med Prim Care [Internet]. 2022;11(11):6752. [cited 2023 Oct 29]. Tersedia dari: https://journals.lww.com/10.4103/jfmpc.jfmpc_1877_21
Healy KO, Waksmonski CA, Altman RK, Stetson PD, Reyentovich A, Maurer MS. Perioperative outcome and long-term mortality for heart failure patients undergoing intermediate- and high-risk noncardiac surgery: impact of left ventricular ejection Fraction. Congest Heart Fail. 2010;16(2):45–9.
Kurniawaty J, Setianto BY, Supomo -, Widyastuti Y, Boom CE. The effect of low preoperative ejection fraction on mortality after cardiac surgery in Indonesia. Vasc Health Risk Manag. Internet]. 2022;18:131–7. [cited 2023 Nov 19]. Tersedia dari: https://www.dovepress.com/the-effect-of-low-preoperative-ejection-fraction-on-mortality-after-ca-peer-reviewed-fulltext-article-VHRM
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