Preeklampsia dan Risiko Penyakit Kardiovaskuler di Masa Depan
Abstract
Preeklampsia adalah gangguan kehamilan spesifik yang mengakibatkan hipertensi dan disfungsi multiorgan, merupakan penyebab utama kematian ibu di seluruh dunia dan mempengaruhi 2% hingga 8% dari semua kehamilan. Didefinisikan sebagai timbulnya hipertensi setelah kehamilan 20 minggu dengan proteinuria, disfungsi organ, atau disfungsi uteroplacental. Ada bukti bahwa efek ini bertahan setelah bayi dilahirkan. Menurut American College of Obstetricians and Gynecologists, faktor risiko untuk terjadi preeklampsia adalah obesitas, hipertensi kronis, diabetes mellitus, penyakit ginjal kronis, preeklampsia sebelumnya, lupus eritematosus sistemik, usia >40 tahun, primiparitas, kehamilan ganda, fertilisasi in vitro, dan riwayat keluarga preeklampsia. Preeklampsia dikaitkan dengan insiden di masa depan untuk peningkatan kejadian gagal jantung 4 kali lipat dan peningkatan risiko penyakit jantung koroner, stroke, dan kematian karena jantung koroner atau penyakit kardiovaskular 2 kali lipat. Pre-eklampsia terkait dengan risiko serangan jantung empat kali lipat lebih tinggi dalam satu dekade setelah melahirkan. Oleh karena itu, penting dilakukan pemantauan faktor risiko kardiovaskular seumur hidup pada wanita dengan riwayat preeklampsia.
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